Flash. Endo Cortisol-synthesis inhibitors

Ketoconazole is often prescribed for Cushing's syndrome to suppress the overproduction of cortisol.

The hepatic system; these drugs can cause hepatotoxicity, evidenced by elevated liver enzymes and jaundice.

These drugs, especially ketoconazole, can cause or exacerbate liver damage. Regular monitoring of liver function tests is essential in these patients.

Dosing should be titrated based on the patient's 24-hour urinary free cortisol levels and clinical symptomatology to avoid adrenal insufficiency.

Regularly monitor patients for signs of adrenal insufficiency, such as fatigue, nausea, vomiting, and hypotension, and regularly check liver function tests, especially when using drugs like ketoconazole.