Flash. Neuro. Alzheimer’s drugs

Cholinesterase inhibitors, such as donepezil, rivastigmine, and galantamine, are commonly prescribed for early Alzheimer's symptoms.

They work by inhibiting the breakdown of acetylcholine, a neurotransmitter involved in memory and learning, in the brain.

Nausea is a common side effect of donepezil.

Memantine.

The patient's heart rate should be monitored, as bradycardia is a potential side effect.

Galantamine should be taken with food.

Yes, off-label administration without appropriate evidence or documentation can result in legal issues and potential harm to the patient.

There's a risk of reduced effectiveness of the cholinesterase inhibitor due to opposing mechanisms of action.

Consistent administration helps maintain therapeutic drug levels and optimize effectiveness.

Bradycardia or slow heart rate.

By educating them about the importance of adherence, potential side effects, and how to administer the medication properly.

No, they can only help manage symptoms and may slow the progression of the disease.

The nurse should use therapeutic communication, ensure the patient's understanding, and explore the reasons for refusal while documenting the incident.

To evaluate the drug's effectiveness and determine if any dose adjustments are needed.

High sodium intake should be avoided as it can reduce the drug's effectiveness.

Memantine is excreted through the kidneys; impaired renal function can lead to increased drug levels and potential toxicity.

Gradual dose changes, either titration up or tapering down, are preferred to minimize side effects.

The nurse could face legal action, potential loss of licensure, and disciplinary measures by the employing institution.

Inform them about potential side effects, how to manage them, and when to seek medical attention.

Education ensures understanding of the drug's purpose, administration, potential side effects, and ensures adherence to the medication regimen.