Flash.Reproductive. Selective Estrogen Receptor Modulators

Unilateral calf pain or swelling, as it may indicate deep vein thrombosis.

The patient should be informed of the increased risk of thromboembolic events, such as deep vein thrombosis and pulmonary embolism, and to report symptoms like leg pain, chest pain, or shortness of breath immediately.

A history of venous thromboembolism, including deep vein thrombosis, pulmonary embolism, or retinal vein thrombosis.

Raloxifene can also reduce the risk of invasive breast cancer in postmenopausal women.

The nurse should advise the patient to stop taking the medication and consult the healthcare provider immediately, as tamoxifen has been linked to retinal changes and cataract formation.